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Toshio MIYATA

 

Professor

 

Toshio MIYATA

M.D., Ph.D.

 

 

The Science News (January 1, 2013)

 

Affiliation

Professor,Tohoku University Graduate School of Medicine

Executive Advisor to the Dean

Associate Executive Vice President,Tohoku University

Vice Executive Director, Office of Research Promotion, Tohoku University


Concurrent post

Member of Royal Academy of Medicine in Belgium, Permanent (2004~)

Advisor to the President for Science and Technology Japan Agency for Medical Research and Development (2015~)

Visiting Professor, North Western University Feinberg School of Medicine (2012~)

Tokai University Visiting Professor

 

Biographical Sketch

Prof. Miyata was born in 1961 in Japan and took M.D. and Ph.D. at Nagoya University School of Medicine in 1986 and 1991, respectively. He is a permanent member of Royal Academy of Medicine in Belgium, a member of Executive Committee and Council in the International Society of Nephrology (ISN), and Chair of the Committee of the Strengthening the Partnership between JSN and ISN in the Japanese Society of Nephrology (JSN). Among 250 published contributions in English include the identification of genes and attendant molecular disorders in various hereditary diseases, the delineation of mechanisms involved in the genesis of diabetic nephropathy and their prevention, of the molecular abnormalities of uraemic toxicity (carbonyl stress) and their treatment, of the roles of bioactive molecules and their inhibition (PAI-1, oxygen sensor, megsin, etc). His lab currently develops a new research area that combines medical science, structural biology, chemistry, pharmacology, and computer engineering to translate several molecules identified by basic research into clinical medicine. Projects are now at preclinical stage (PAI-1 inhibitor, oxygen sensor inhibitor) or at Phase IIa clinical study (carbonyl stress inhibitor).

 

Awards

2002 The Japanese Society of Molecular Medicine Award

2001 Japan Foundation for Aging and Health Award
1995 Oshima Award of the Japanese Society of Nephrology

1993 Young Investigator Award of the Japanese Society of Internal Medicine

1991 Nagoya Memorial Award

 

Publications

 Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress.Itokawa M, Miyashita M, Arai M, Dan T, Takahashi K, Tokunaga T, Ishimoto K, Toriumi K, Ichikawa T, Horiuchi Y, Kobori A, Usami S, Yoshikawa T, Amano N, Washizuka S, Okazaki Y, Miyata T.

Psychiatry Clin Neurosci. 2018;72(1):35-44.

Pyridoxamine A novel treatment for schiz
Adobe Acrobat Document 734.9 KB

 A null mutation in SERPINE1 protects against biological aging in humans.Khan SS, Shah SJ,Klyachko E, Baldridge AS, Eren M, Place AT, Aviv A, Puterman E, Lloyd-Jones DM, Heiman M, Miyata T, Gupta S, Shapiro AD, Vaughan DE.

Science Advances.2017;3:eaao1617.

Science Advances 2017 3eaao1617.pdf
Adobe Acrobat Document 1.7 MB

 TGF-β-induced intracellular PAI-1 is responsible for retaining   hematopoietic stem cells in the niche.

Yahata T, Ibrahim A, Muguruma Y, Eren M, Shaffer AM, Watanabe N, Kaneko S, Nakabayashi N, Dan T,   Hirayama N, Vaughan DE, Miyata T, Ando K.

Blood.2017;130(21):2283-2294.

2283.full.pdf
Adobe Acrobat Document 1.8 MB

 PAI-1 is a critical regulator of FGF23 homeostasis.

Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE.

Science Advances.2017;3: e1603259

Science FGF23.pdf
Adobe Acrobat Document 772.7 KB

 Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.

Honjo T, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.

The FASEB Journal.2017 ;31:2625-2637

FASEB J-2017-Honjo-fj.201600871RR.pdf
Adobe Acrobat Document 6.4 MB

 

A small molecule inhibitor of PAI-1 protects against Doxorubicin-induced cellular senescence: molecular basis.

Ghosh AK, Rai R, Park KE, Eren M, Miyata T, Wilsbacher LD, Vaughan DE.

Oncotarget.2016; 7:72443-72457

oncotarget.pdf
Adobe Acrobat Document 1.5 MB

Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma.

Liu RM, Eldridge S, Watanabe N, Deshane J, Kuo HC, Jiang C, Wang Y, Liu G, Schwiebert L, Miyata T, Thannickal VJ.

Am J Physiol Lung Cell Mol Physiol.2016; 15: 328-336.

Am J Physiol Lung Cell Mol Physio 2016 1
Adobe Acrobat Document 1.2 MB

 

Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model.

Jeong BY, Uddin MJ, Park JH, Lee JH, Lee HB, Miyata T, Ha H.

PLoS One.2016; 11: e0157012.

Plos one 2016 11 e0157012.pdf
Adobe Acrobat Document 3.2 MB

 

A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice.

Piao L,Jung I, Huh JY, Miyata T, Ha H.

British J Pharmacology.2016; 173:2622-2632.

British J Pharmacology 2016 173 2622-263
Adobe Acrobat Document 1.1 MB

 

Delayed intervention with pyridoxamine improves metabolic function and prevents adipose tissue inflammation and insulin resistance in high-fat diet-induced obese mice.

Maessen DE, Brouwers O, Gaens KH, Wouters K, Cleutjens JP, Janssen BJ, Miyata T, Stehouwer CD, Schalkwijk CG.

Diabetes.2016; 65: 956-966.

No268_Diabetes 2016 65 956-966.pdf
Adobe Acrobat Document 2.1 MB


Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.

Placencio VR, Ichimura A, Miyata T, DeClerck YA.

PLoS One.2015; 10: e0133786.

PLoS One 2015 10 e0133786.pdf
Adobe Acrobat Document 3.5 MB

 

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N.

J Am Soc Nephrol.2016; 27: 428-438.

J Am Soc Nephrol 2015.pdf
Adobe Acrobat Document 2.5 MB


Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis.

Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele de Strihou C, Miyata T.

PLoS One. 2015; 10: e0124510.

PLoS One 2015 10 e0124510.pdf
Adobe Acrobat Document 6.8 MB

 

Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via beta 1 integrin endocytosis.

Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, Nagata M.

Am J Physiol Renal Physiol.2015; 308:F614-26.

Am J Physiol Renal Physiol 2015 308 F614
Adobe Acrobat Document 7.7 MB

 

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren M, Boe A, Murphy SB, Place AT,  Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GS, Mutlu GM, Miyata T, Vaughan DE.

Proc Natl Acad Sci USA. 2014; 111: 7090-7095.

Proc Natl Acad Sci USA 2014 111 7090-70
Adobe Acrobat Document 1.3 MB

 

Drug discovery in renal disease —towards a more efficient framework

Miyata T, Ando T, Hiragi H, Watanabe K, Yamamoto F, Vaughan DE, Kurokawa T, Oshima Y, van Ypersele de Strihou C, Takeuchi M.

Nat Rev Nephrol 2014; 10: 290-296.

Nat Rev Nephrol 2014 10 290-296..pdf
Adobe Acrobat Document 759.2 KB

 

Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration

Ibrahim AA, Yahata T, Onizuka M, Dan T, van Ypersele de Strihou C, Miyata T, Ando K.
Stem Cells 2014; 32: 946-958.

Stem Cells 2014 32 946-58..pdf
Adobe Acrobat Document 856.8 KB

 

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes

Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG.
Diabetologia 2014; 57: 224-235.

Diabetologia 2014 57 224-235..pdf
Adobe Acrobat Document 620.5 KB

 

The PAI-1 antagonist TM5441 attenuates L-NAME-induced

hypertension and vascular senescence
Boe A, Eren M, Murphy S, Kamide1 C, Ichimura A, Terry D, McAnally D, Smith LH, Miyata T, Vaughan DE.
Circulation 2013; 128: 2318-2324.

Circulation 2013 128 2318-2324..pdf
Adobe Acrobat Document 1.1 MB

 

Kidney failure: aims for the next 10 years and barriers to success

Remuzzi G, Benigni A, Finkelstein FO, Grunfeld JP, Joly D, Katz I, Liu ZH, Miyata T, Perico N, Rodriguez-Iturbe B, Antiga L, Schaefer F, Schieppati A, Schrier RW, Tonelli M.

Lancet 2013; 382: 353-362.

Lancet 2013 382 353-362..pdf
Adobe Acrobat Document 5.9 MB

 

Diabetic nephropathy: Are there new and potentially promising therapies targeting oxygen biology?

Miyata T, Suzuki N, van Ypersele de Strihou C.

Kidney Int 2013; 84: 693-702.

Kidney Int 2013 84 693-702..pdf
Adobe Acrobat Document 1.2 MB

 

A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration

Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou C, Miyata T.

Arterioscler Thromb Vasc Biol. 2013; 33: 935-942.

Arterioscler Thromb Vasc Biol 2013 935-
Adobe Acrobat Document 2.2 MB

 

Metabolic stress response implicated in diabetic retinopathy:the role of calpain, and the therapeutic impact of calpain inhibitor.

Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Takaomi S, Minegishi N, Miyata T, Abe T, Yamamoto M.

Neurobiology of Disease 2012; 48: 556-567.

Neurobiology of Disease 2012 48 556-567.
Adobe Acrobat Document 2.1 MB

 

The receptor of advanced glycation end products (RAGE) plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

Zhou LL, Cao W, Xie C, Tian J, Zhou Z, Zhou Q, Zhu P, Li A, Liu Y, Miyata T, Hou FF, Nie J.

Kidney Int 2012; 82 759-770

Kidney Int 2012 82 759-770.pdf
Adobe Acrobat Document 527.3 KB

 

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.

Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K.

Blood 2012; 119: 6382-6393.

Blood 2012 119 6382-6393.pdf
Adobe Acrobat Document 940.1 KB

 

Protection against methylglyoxal-derived AGEs by regulation of glyoxalse-1 prevents retinal neuroglial and vasodegenerative pathology.

Berner AK, Brouwers O, Pringle R, Klaassen I, Colhoun L, McVicar C, Brockbank S, Curry JW, Miyata T, Brownlee M, Schlingemann RO, Schalkwijk C, Stitt AW.

Diabetologia 2012; 55: 845-854.

Diabetologia 2012 55 845-854.pdf
Adobe Acrobat Document 579.5 KB

 

Skin advanced glycation end product accumulation is negatively associated with calcaneal osteo-sono assessment index among non-diabetic adult Japanese men.
Momma H, Niu K, Kobayashi Y, Guan L, Sato M, Guo H, Chujo M, Otomo A, Yufei C, Tadaura H, Saito T, Mori T, Miyata T, Nagatomi R.

Osteoporos Int 2012; 23: 1673-1681.

Osteoporos Int 2012 23 1673-1681.pdf
Adobe Acrobat Document 396.7 KB

 

Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis.

Huang WT, Vayalil PK, Miyata T, Hagood J, Liu RM.

Am J Respir Cell Mol Biol. 2012; 46: 87-95.

Am J Respir Cell Mol Biol 2012 46 87-95
Adobe Acrobat Document 1.7 MB

 

Glyoxalase-I retards renal senescence.

Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M.

Am J Pathol 2011; 179: 2810-2821.

Am J Pathol 2011 179 2810-2821.pdf
Adobe Acrobat Document 2.7 MB

 

New era for drug discovery and development in renal disease.

   Miyata T, Kikuchi K, Kiyomoyo H,van Ypersele de Strihou C.

   Nat Rev Nephrol 2011;7:469-477.

Nat Rev Nephrol 2011 7 469-477.pdf
Adobe Acrobat Document 761.1 KB

 

In Oxidative Stress in Applied Basic Research and Clinical Practice: Studies on Renal Disorders (Springer), edited by Toshio MIyata, Kai-Uwe Eckardt, Masaomi Nangaku.

Studies on Renal Disorders.pdf
Adobe Acrobat Document 75.6 KB

 

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets.

Miyata T, Takizawa S,van Ypersele de Strihou C.

Am J Physiol Cell Physiol 2011;300:226-231.

Am J Physiol Cell Physiol 2011 300 226-2
Adobe Acrobat Document 605.0 KB

 

Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients.

Kakuta T, Tanaka R, Hyodo T, Suzuki H, Kanai G, Nagaoka M, Takahashi H, Hirawa N, Oogushi Y, Miyata T, Kobayashi H, Fukagawa M, Saito A.

Am J Kidney Dis 2011;57:422-431.

Am J Kidney Dis 2011 57 422-431.pdf
Adobe Acrobat Document 1.4 MB

 

Overexpression of Glyoxalase-I Reduces Hyperglycemia–induced Levels of Advanced Glycation Endproducts and Oxidative Stress in Diabetic Rats.

Brouwers O, Niessen PM, Ferreira I, Miyata T, Scheffer PG, Teerlink T, Schrauwen P, Brownlee M, Stehouwer CD, Schalkwijk CG.

J Bio Chem. 2011 ;286:1374-1380.

J Biol Chem. 2011 286 1374-1380.pdf
Adobe Acrobat Document 1.1 MB

 

Enhanced carbonyl stress in a subpopulation of schizophrenia.

Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A,Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M.  

Arch Gen Psychiatry 2010; 67: 589-597.

Arch Gen Psychiatry 2010 67 589-597.pdf
Adobe Acrobat Document 180.3 KB

 

Diabetic nephropathy: a disorder of oxygen metabolism?

Miyata T, van Ypersele de Strihou C.

Nat Rev Nephrol. 2010;6:83-95.

Nat Rev Nephrol. 2010 6 83-95.pdf
Adobe Acrobat Document 707.1 KB

Total publications in English

Total of 234 peer-reviewed contributions in English (Total impact factor 1,192 points; Total citation factors 9,448 points; H-index is 53).

See also Research Information.


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